نتایج جستجو برای: عملکرد TBM

تعداد نتایج: 101273  

2013
Suzaan Marais Graeme Meintjes Dominique J. Pepper Lori E. Dodd Charlotte Schutz Zahiera Ismail Katalin A. Wilkinson Robert J. Wilkinson

BACKGROUND Tuberculosis immune reconstitution inflammatory syndrome (IRIS) is a common cause of deterioration in human immunodeficiency virus (HIV)-infected patients receiving tuberculosis treatment after starting antiretroviral therapy (ART). Potentially life-threatening neurological involvement occurs frequently and has been suggested as a reason to defer ART. METHODS We conducted a prospec...

2014
Suzaan Marais Katalin A. Wilkinson Maia Lesosky Anna K. Coussens Armin Deffur Dominique J. Pepper Charlotte Schutz Zahiera Ismail Graeme Meintjes Robert J. Wilkinson

BACKGROUND The immunopathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) remains incompletely understood, and we know of only 1 disease site-specific study of the underlying immunology; we recently showed that Mycobacterium tuberculosis culture positivity and increased neutrophils in the cerebrospinal fluid (CSF) of patients with tuberculous meningitis (TB...

Journal: :BMC Neurology 2006
Anju V Mudaliar Rajpal S Kashyap Hemant J Purohit Girdhar M Taori Hatim F Daginawala

BACKGROUND Diagnosis of tuberculous meningitis (TBM) is difficult. Rapid confirmatory diagnosis is essential to initiate required therapy. There are very few published reports about the diagnostic significance of 65 kD heat shock protein (hsp) in TBM patients, which is present in a wide range of Mycobacterium tuberculosis species and elicits a cellular and humoral immune response. In the presen...

Journal: :Developmental Immunology 1998
John P. Smith Gregory F. Burton John G. Tew Andras K. Szakal

Tingible body macrophages (TBM), long thought simply as scavengers of apoptotic lymphocytes, are located in the unique microenvironment of germinal centers in close proximity to antigen-retaining follicular dendritic cells (FDC). Observations that TBM endocytose FDC-iccosomal (immune-complex coated bodies) antigen suggested that TBM might present this antigen and help regulate the germinal cent...

2013
Ruchika K. Jain Amit R. Nayak Aliabbas A. Husain Milind S. Panchbhai Nitin Chandak Hemant J. Purohit Girdhar M. Taori Hatim F. Daginawala Rajpal S. Kashyap

The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein of Mycobacterium tuberculosis (MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n = 31), suspected latent TBM (n = 22), and suitable noninfectious control subjects (n = 47) were collected and evaluated for Rv2623 antigen level using...

Journal: :Indian pediatrics 1994
V Gupta V K Agarwal S Mathur V N Tripathi A Agarwal M Bhalla A Khadwal

Modified Levinson's precipitation test was done in 64 cases of TBM, 54 cases of TBM with inconsistent CSF finding, and 32 cases of pyogenic meningitis. The test was positive in 93.7% cases of TBM (sensitivity, 93.7%), 85.5% cases of TBM with doubtful diagnosis and in 9.4% cases of pyogenic meningitis (specificity 90.6%) compared to 79.7%, 72.2% and 18.8% in original Levinson's test, respectivel...

Journal: :American journal of respiratory and critical care medicine 2006
Mostafa Ghanei Farhad Akbari Moqadam Mehdi Mir Mohammad Jafar Aslani

RATIONALE Mustard gas primarily affects the eyes, skin, and particularly the respiratory tract. Tracheobronchomalacia (TBM) and air trapping are often observed in high-resolution computerized tomography (HRCT) scans of the chest of mustard gas-exposed patients. OBJECTIVES To examine the frequency and severity of TBM in a group of Iranian wartime mustard gas-exposed victims, and to investigate...

2016
Ting Wang Guo-Dong Feng Yu Pang Yi-Ning Yang Wen Dai Lin Zhang Lin-Fu Zhou Jia-Lei Yang Li-Ping Zhan Ben J. Marais Yan-Lin Zhao Gang Zhao

Background: Microbiological confirmation of tuberculous meningitis (TBM) remains problematic. We assessed the diagnostic performance of a modified Ziehl-Neelsen (MZN) staining method that showed promise in earlier studies. Methods: Patients evaluated for TBM in Shaanxi province, China, were prospectively enrolled from May, 2011 to April, 2013. Cerebrospinal fluid (CSF) specimens were evaluated ...

2010
Fiju Chacko Manish Modi Vivek Lal S Prabhakar S.V. Rana S.K. Arora

BACKGROUND The rapid diagnosis of Tubercular meningitis (TBM) is fundamental to clinical outcome. The key to diagnosis lies in Cerebrospinal fluid (CSF) analysis and radiological investigations. There are numerous lacunae in the confirmation of diagnosis of TBM from CSF. PURPOSE The aim of present study was to compare the efficacy of CSF adenosine deaminase (ADA) level assays and Polymerase c...

2012
Sagarika Haldar Naveen Sankhyan Neera Sharma Anjali Bansal Vitul Jain V. K. Gupta Monica Juneja Devendra Mishra Arti Kapil Urvashi B. Singh Sheffali Gulati Veena Kalra Jaya Sivaswami Tyagi

BACKGROUND Tuberculous meningitis (TBM) is the most common form of neurotuberculosis and the fifth most common form of extrapulmonary TB. Early diagnosis and prompt treatment are the cornerstones of effective disease management. The accurate diagnosis of TBM poses a challenge due to an extensive differential diagnosis, low bacterial load and paucity of cerebrospinal fluid (CSF) especially in ch...

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